The efficiency of oat bran and barley bran in lowering the induced hyperlipidemia and hypercholesterolemia in blood of male\r\nAlbino rats (Rattus rattus) was studied. Twenty rats were divided into four groups each consisted of five rats and fed the specified\r\ntest diets for eight weeks. The first group (G1) is the negative group which was fed basal diet, the second group (G2) was fed 1.0%\r\ncholesterol, was the third group (G3) fed 1.0% cholesterol and 10% oats bran, and the fourth group (G4) was fed 1.0% cholesterol\r\nand 10% barley bran. Feeding rats on 1% cholesterol significantly increased serum total cholesterol, low density lipoprotein, and\r\nvery low density lipoprotein and triglyceride and decreased serum high density lipoprotein. Furthermore, enzyme activity of\r\nalanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase was increased, and lipid peroxide was increased,\r\nwhereas catalase and glutathione-S-transferase were decreased. Kidney functions parameters in the cholesterol supplemented\r\ngroup were elevated compared with the negative control. In addition, histological alteration in kidney, liver, heart, and testes was\r\nobserved, compared with the negative control. Hypercholesterolemic rats supplemented with oat bran and barley bran showed\r\nsignificant decrease in lipid parameters, significant increase in high density lipoprotein-cholesterol, improved antioxidant enzyme,\r\nand improved histopathology of kidney, liver, heart, and testes. In conclusion, both oat bran and barley bran had protective effects\r\nagainst induced hyperlipidemia and improved histological alterations.Oat bran appearedmore efficient than barley bran in lowering\r\nthe lipid profile levels in hypercholesterolemic rats.
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